YTHDF2 and melanoma: In addition, in the melanoma mouse model, YTHDF2+ macrophages weakened their MHCI-like antigen cross-presentation function, thus reducing the activation and infiltration of CD8+T cells, while YTHDF2+ macrophages reduced the stability of their STAT1 mRNA, and were more likely to be induced into the M2 polarization phenotype [56].