IDH3A and glioblastoma: For example, in a sample of adult diffuse gliomas, the histological properties of isocitrate dehydrogenase wild-type glioblastoma (GBM-IDH-WT, grade 4) indicate microangiogenesis and necrosis, with IBA1+/CXCL3+TAMs located primarily in the perinecrotic area and IBA1+/TMEM119+TAMs located near microvessels [25].