In RC, TG2 is not only critical for cancer cell adhesion, migration, and invasiveness during RC progression and propagation, but reducing TG2 expression decreases the adhesion of ITGB1, fibronectin, type I collagen, and laminin by 60% and decreases the expression of CD44, CD73, and CD105 CSC-like markers [72]. The gene discussed is TGM2; the disease is cancer.