Cancer exosomes upregulate fibroblast proteins implicated in focal adhesion (α2/α6/αv, β1/β4/β5, EGFR, CRK), regulators of actin cytoskeleton (RAC1, ARF1, ARPC3, CYFIP1, NCKAP1, ICAM1, and ERM complex), and signaling pathways (MAPK, Rap1, RAC1, and Ras) important in pro-invasive remodeling of ECM, which leads to the creation of pre-metastatic niches [102]. This evidence concerns the gene RAC1 and cancer.