FN1 and cancer: Cancer-associated fibroblasts, the most numerous tumor stromal cells in TME, for example, express a range of integrins, including integrins αvβ3 [82], α5β1 [83], and α11 [84, 85], which are involved in the assembly of fibronectin in the ECM and can promote the conversion of fibronectin matrix to fibronectin and the deposition of CAFs in the tumor stroma [38].