With adjustment for socioeconomic status and lifestyle factors, MC4R gene polymorphisms were significantly associated with obesity under dominant, codominant, and additive inheritance models (Rs17782313 genotype T/C + C/C vs. T/T OR = 1.61, 95%CI: 1.12 ~ 2.33; genotype T/C vs. T/T OR = 1.59, 95%CI: 1.08 ~ 2.33; additive model OR = 1.45, 95%CI: 1.07 ~ 1.95. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.