Our study demonstrated that the genotype CC and the frequency of allele C in the SLCO1B3-rs2417940 significantly correlated to the incidence of hyperbilirubinemia (81.3% vs. 58.0%, P = 0.002, OR 2.989 and 90.6% vs. 78.0%, P = 0.001, OR 2.726, respectively). This evidence concerns the gene SLCO1B3 and Hyperbilirubinemia.