Allele frequencies analysis revealed that the rs4148323 A allele in UGT1A1 gene and the allele C of SLCO1B3-rs2417940 were associated with hyperbilirubinemia (OR 2.897, p = 0.001 and OR 2.726,P = 0.001, respectively). The gene discussed is UGT1A1; the disease is Hyperbilirubinemia.