BAX and intrahepatic cholangiocarcinoma: Consistent with this result, western blotting also revealed that the apoptosis-related proteins BAX, cleaved-Caspase3, and cleaved-Caspase9 were significantly upregulated, whereas that of anti-apoptotic BCL-2 was significantly downregulated in ICC cells overexpressing FOXP1 (Fig. 4C-E).