The apoptosis-related proteins (BAX, cleaved-Caspase3, and cleaved-Caspase9) were elevated, and the anti-apoptotic protein BCL-2 was downregulated after overexpression of FOXP1, suggesting that cell apoptosis may be a part of the FOXP1-induced ICC suppression mechanism. Here, BAX is linked to intrahepatic cholangiocarcinoma.