CD274 and neoplasm: Instead, they have paid more attention to biomarkers associated with several hot topics, such as PDL-1 expression (Dong et al. 2002; Freeman et al. 2000; Topalian et al. 2012), tumor mutational burden/neo-antigens (Charoentong et al. 2017), interferon-γ gene signature (Woo et al. 2015), and tumor microenvironment (Ager and May 2015).