We demonstrated that the formation of destruction complex condensates depends on the β-catenin accumulation of high concentrations, APC mutations prevent Axin from recruiting GSK3β and CK1α into the condensates, and Axin is related to the β-catenin nuclear translocation and its transcriptional function as a droplet, which could drive CRC initiation and progression (Fig. 6). Here, GSK3B is linked to colorectal carcinoma.