USP2 and ovarian neoplasm: Conversely, an array of deubiquitinases (Dubs), including dUsp36 (Drosophila ubiquitin-specific protease 36) (Thevenon et al, 2009), Cyld (cylindromatosis) (Tsichritzis et al, 2007), Faf (fat facets) (Yagi et al, 2013), Usp2 (ubiquitin-specific protease 2) (Engel et al, 2014), dTrabid (Drosophila TRAF-binding domain-containing protein) (Fernando et al, 2014), and Otu (ovarian tumor) (Ji et al, 2019), has been identified as essential regulators in restricting the ubiquitination level of some key factors of the IMD pathway.