A salient finding in the present study is the identification of peripheral blood monocyte gene co-expression related to inflammatory processes in high-SI participants, with enrichment of genes in Pyroptosis Signaling, TREM1 Signaling, NF-κB signaling, T Cell Receptor Signaling, Systemic Lupus Erythematosus In B Cell Signaling, Calcium-induced T Lymphocyte Apoptosis, and trend wise enrichment of genes in neuroinflammation pathways in the high SI vs. no SI groups. The gene discussed is TREM1; the disease is systemic lupus erythematosus.