In both ALS/FTLD–TDP motor cortex and C9orf72-linked FTLD–TDP hippocampus, TC1HDG immunoreactivity was seen specifically in nuclei of neurons displaying nuclear clearance of TDP-43 accompanied by phosphorylated TDP-43 cytoplasmic aggregates (Fig. 3). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.