Elevated cryptic HDGFL2 signal ratios were not correlated with revised ALS functional rating scale scores in C9orf72-linked ALS or ALS–FTD (r = −0.31, P = 0.13), or in sporadic ALS (r = 0.36, P = 0.15). The gene discussed is HDGFL2; the disease is amyotrophic lateral sclerosis.