KRAS and cancer: In addition, when we investigated a distinct large-scale drug sensitivity database (GDSC1, Genomics of Drug Sensitivity in Cancer) available at (www.cancerrxgene.org) that utilizes IC50 values of the given drugs, we found that KRAS-G12C LUAD cell lines had significantly lower ln(IC50) values upon FTI277 treatment compared to wild type cells (Fig. 1b).