From stage IC1 to stage IC2, clear changes occurred at the cellular and molecular levels including epithelial cell differentiation potential significantly increased, the tumor cell function such as apoptosis, DNA damage, and metastasis function evidently enhanced; CD8+ exhausted T cells and Treg cell proportions were distinctly increased, and corresponding genes expression level were up-regulated; the expression of ECM-related genes in myCAF were also up-regulated. The gene discussed is CD8A; the disease is neoplasm.