Finally, the protective ProDiGY association in SLC30A8 (OR 0.35, P = 6.0 × 10−4) had a larger effect size than observed in AMP-T2D-GENES, suggesting that youth-onset T2D risk is influenced not only by risk-increasing variants but also by a depletion (even relative to adult-onset cases) of protective variants. Here, SLC30A8 is linked to type 2 diabetes mellitus.