These findings demonstrate that the major CD4+ T cell response to primary infection with SARS-CoV-2 MA10 in HLA-DRB1∗0101 Ifnar1−/− mice is Th1-biased, which is consistent with human studies showing that SARS-CoV-2 infection or vaccination elicits CD4+ T cells with a Th1-like phenotype23,83,84. The gene discussed is CD4; the disease is infection.