However, Tg2576‐PMX205 treated mice did show reduced VGlut1 puncta localized within the microglial lysosomes (vs. Tg2576‐H2O mice) (Figure 5C6), consistent with our previous data in the Arctic model of AD and suggesting an improved lysosomal efficiency when C5aR1 signaling is suppressed. The gene discussed is C5AR1; the disease is Alzheimer disease.