NEUROD1 and small cell lung carcinoma: Recently, it has been shown that DNA methylation, as a surrogate to gene expression, can be used for the development of prognostic signatures as well as to differentiate ASCL1-dominant SCLC and NEUROD1-dominant SCLC from a third group of SCLC which is highlighted by the absence of ASCL1 or NEUROD1 dominance 21.