CXCL12 and neoplasm: Indeed, in samples with subtype switching we saw marked differences in the promoter methylation of immune-related genes, such as CXCL12 (T cell recruitment), CIITA (antigen presentation machinery transcription), STAT1 (inflammatory gene transcription) as well as the interferon alpha and gamma receptors (IFNRA1, IFNRA2, IFNGR1) highlighting profound changes in the tumor:immune phenotypes (Figure S9B).