In addition, the expression level of ASB16-AS1 correlated negatively with Ki-67 index, tumor size, tumor stage, lymph node metastasis, distant metastasis, and lymph node metastasis.[124] The mRNA expression of HOTAIR in 77 ACC tissues and 30 normal adrenal tissues was detected by qRT-PCR. Here, MKI67 is linked to neoplasm.