Previous studies have shown that salmonella infection might lead to left ventricular hypertrophy, causing cardiovascular complications.[21,22] Recent studies have shown that the Renin-angiotensin system plays an essential role in the etiology of cardiomyopathy and can be used as a therapeutic target.[23,24] In addition, PPI network analysis identified 8 hub genes-STAT3, PTPN11, LY96, IRAK3, ANXA2, CD14, CEBPB, and CTSG. This evidence concerns the gene ANXA2 and left ventricular hypertrophy.