Among proteins showing the highest enrichment in the mGlu2 interactome, we focused on BDNF/NT-3 growth factor receptor TrkB (also called NTRK2, highlighted in green), given the well-documented influence of the BDNF/TrkB axis on the pathophysiology of schizophrenia (Fig. 1B and table S1) (15). This evidence concerns the gene BDNF and schizophrenia.