The interaction analysis further highlighted the potential combined effect of GCKR, ADH1B, ALDH1A1, and ALDH2 with rs671 GA toward increased (GCKR, ADH1B, and ALDH1A1) or decreased (ALDH2) risk of esophageal cancer and thereby carries important implications for personalized prevention. Here, GCKR is linked to esophageal cancer.