Given that esophageal cancer, especially squamous cell carcinoma, which is a predominant subtype in East Asians, is strongly associated with alcohol consumption and shows sufficient evidence for a gene-environment interaction between ALDH2 and alcohol drinking (41), esophageal cancer represents a suitable target to assess the impact of the seven identified variants in the rs671 genotype-stratified GWAS (rs1260326 in GCKR, rs28712821 in KLB, rs1229984 in ADH1B, rs2228093 in ALDH1B1, rs8187929 in ALDH1A1, rs79463616 in ALDH2, and rs73550818 in GOT2) on alcohol-related disease risk. This evidence concerns the gene GCKR and squamous cell carcinoma.