Of the seven identified variants in the rs671 genotype-stratified GWAS, five variants (rs1260326 in GCKR, rs28712821 in KLB, rs1229984 in ADH1B, rs8187929 in ALDH1A1, and rs79463616 in ALDH2) were shown to be associated with esophageal cancer risk, exhibiting the same direction of association as the genotype-stratified GWAS. The gene discussed is ADH1B; the disease is esophageal cancer.