Given that cGAS and STING contribute to the development of intestinal inflammation and cancer by restricting the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and activation of nuclear factor κB (NF-κB), respectively (8, 9), we investigated the role of Ku70 in STAT3 and NF-κB signaling. The gene discussed is XRCC6; the disease is inflammatory response.