JAG2 and cardiovascular disorder: In addition to its involvement in normal physiological processes, Jag2is implicated in various diseases including cancer and cardiovascular disorders [26, 27]:Jag2 is upregulated in cancer cells and promotes tumor growth and progression by activating Notch signaling pathways [27], whilein cardiovascular disorders, Jag2 is involved in the regulation of vascular smooth muscle cell proliferation, migration, and angiogenesis [28].