CGAS and melanoma: Within the group of DNA sensors, TLR9 detects unmethylated DNA, RNA polymerase III (POL III) recognizes AT-rich DNA, while absent in melanoma (AIM)2, gamma-interferon-inducible protein 16 (IFI16) and cyclic GMP-AMP synthase (cGAS) senses double-stranded (ds) DNA in a sequence-independent manner [20, 21].