Regarding the classification of locally advanced pancreatic cancer (n = 14) or metastatic pancreatic cancer (n = 4), there was no difference between the two groups in KRAS-mutated ctDNA MAF values at pretreatment (Mann–Whitney U-test, P = 0.7018) (Supplementary Fig. S1). The gene discussed is KRAS; the disease is familial pancreatic carcinoma.