MET and neoplasm: Pre-osimertinib tumor biopsies from patient LAT028 showed MET amplification by copy number (total of 7.7 MET copies; Fig. 5A) and patient LAT021 showed MET polysomy (based on four or more MET signals observed in at least 40% of cells with a MET/CEP7 ratio <2; Fig. 5B).