There is an increase in the concentration of glucagon-like peptide 1 and glucose-dependent insulinotropic peptide, which improves the sensitivity of beta cells of the islets of Langerhans of the pancreas to glucose, increases insulin secretion and improves the activity of alpha cells responsible for the production of glucagon, without disturbing the glucagon response to hypoglycemia. The gene discussed is INS; the disease is Hypoglycemia.