IFIH1 and viral infectious disease: In addition, viral infection results in BALB/C mice revealed that mutant ΔG also upregulated the mRNA expression of cytosolic RNA helicases Mda5 and Rig-I, which recognize double-stranded RNA motifs and uncapped 5′-triphosphates on viral RNA, respectively, and eventually trigger the production of IFNβ in epithelial cells [33].