TLR4 and neoplasm: Immunogenic cell death caused by RT increases damage-associated molecular patterns (DAMPs), made up of group box-1 proteins (HMGB1), impacting toll-like receptor-4 (TLR-4) (and thus dendritic cells), which facilitates more extensive antigen presentation due to the inhibition of intracellular antigen degradation and adenosine triphosphate (ATP), stimulating the aggregation of dendritic cells for antigen presentation in the tumor [73].