In HCC, with Yttrium-90 radioembolization along with an increase in APCs, the CD8+/CD4+ T cells in peripheral blood were associated with the upregulation of the chemokine (CCL)5 and CXC-ligand (CXCL)16 pathways, an increase in the infiltration of CD8+ T cells and NK cells into the tumor, and the subsequent activation of dose- and fractionation-dependent immunosuppressive response [78]. The gene discussed is CD8A; the disease is neoplasm.