AKT1 and cancer: A year later, Q.Z. Hu and others discovered that SIN derivatives 11c (10) displayed pronounced cytotoxicity through the IL-6/PI3K/Akt and NF-κB signaling pathways, with IC50 values of 3.76–10.26 μM against cancer cells (HeLa, A549, HepG-2, MCF-7, and HT-29) [68].