In addition, SIN reversed the H2O2-induced inhibition of the antioxidant enzymes catalase (CAT) and SOD-2 via reducing TGFβ-induced ROS, and it ameliorated the reduced enzyme activities of total SOD and GPx in cultured cells and UUO kidneys, thereby balancing the oxidative stress associated with renal fibrosis. Here, CAT is linked to renal fibrosis.