In 2018, G.L. Gao et al. found that SIN (4 μM) reduced PCNA, CyclinD1, and CDK4, increased p16, and increased cleaved-caspase-3/-9 in MDA-MB-231 and MCF-7 cells by elevating miR-29, leading to the downregulation of p-JNK, p-MEK, and p-ERK, ultimately inhibiting the proliferation, migration, and invasion of breast cancer cells [31]. Here, MAPK8 is linked to breast carcinoma.