CREB1 and cancer: S.P. Chen and team reported that single and repeated administrations of SIN (10–40 mg/kg) alleviated mechanical hypersensitivity in rats with cancer-related bone pain, inhibited microglial activation via the JAK2/STAT3 pathway, and decreased CAMKII/CREB through the inhibition of microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades [107].