HK2 and non-small cell lung carcinoma: In the following year, it was reported that SIN (25–100 μM) inhibited cell migration and decreased p-Histone H3 (Ser10), thereby impeding the growth of non-small-cell lung cancer (NSCLC) cells by inhibiting the activity of Akt and downstream kinase S6, reducing hexokinases 2 (HK2), and hindering glycolysis.