SIAH2 and breast cancer: In the same year, L.Q. Song et al. announced the therapeutic effect of SIN on breast cancer, finding that SIN (0.75 mM) hindered hypoxia-induced vasculogenic mimicry (VM) formation and metastasis of breast cancer SP cells by suppressing the hypoxia-induced downregulation of miR-340–5P and activation of the SIAH2/HIF-1α pathway and inhibiting the epithelial-to-mesenchymal transition of breast cancer SP cells [40].