In 2021, Y.D. et al. reported that SIN (200 μM) inhibited MCP-1, IL-6, and vascular endothelial growth factor, increased A2AR in synovial tissue of AIA rats and FLSs, and inhibited the NF-κB pathway via α7nAChR, thereby alleviating arthritis. The gene discussed is CHRNA7; the disease is arthritic joint disease.