STAT3 and neoplasm: In the same year, T. Xie’s group discovered that SIN (20–400 μM) curbed tumor invasion and metastasis by inhibiting CXCR4 and STAT3 phosphorylation and downregulating MMP-2/-9, VEGF, RANKL, and CD147, thereby impeding the invasion and metastasis of osteosarcoma and hindering angiogenesis in human umbilical vein endothelial cells (HUVEC).