PIK3CB and Sepsis: Sinomenine hydrochloride has also been found to alleviate sepsis induced by cecal ligation puncture (CLP) in BALB/c mice by inhibiting the production of various inflammatory factors like TNF-α [184], while curcumin has demonstrated efficacy against sepsis through pathways such as PI3K/AKT, NF-κB, TNF-α, and TGF-B1 and possesses bactericidal effects against various bacteria [235].