SHPRH and esophageal squamous cell carcinoma: In the same year, S.B. Fu and team discovered that SH inhibited the growth of esophageal squamous cell carcinoma (ESCC) cells (IC20 values were 0.3 mM and 0.4 mM for Eca109 and EC970), induced G2/M phase arrest, downregulated the BcL-2/Bax ratio, cyclin B1, CDK1, Ku86/70, and Rad5 to enhance radiosensitivity.