In 2021, researchers reported that the highly active compound 6d (8) exhibited notable cytotoxicity through the PI3K/AKT and MAPK signaling pathways, with IC50 values ranging from 3.46 μM to 11.51 μM against various cancer cell lines (MCF-7, HeLa, HepG2, SW480, and A549). The gene discussed is AKT1; the disease is cancer.