The GFD reduced serum titers of TPOAb and TGAb in euthyroid women with CAT, which correlated with the increase in the SPINA-GT index. This finding indicates that the GFD may bring clinical benefits to euthyroid women with CAT, who, because of markedly elevated thyroid antibody titers, are at high risk of the development of hypothyroidism. This evidence concerns the gene CAT and hypothyroidism.