The PTT/PDT of GNR@Ag@mSiO2-MB nanostructures could synergistically kill cancer cells via a low power density (0.6 W/cm2) of 785 nm NIR laser for 600 s, indicating that GNR@Ag@mSiO2-MB nanostructures have superior photothermal conversion efficiency and excellent ROS-generating ability. The gene discussed is MB; the disease is cancer.