SDC1 and inflammatory bowel disease: Knowing that the absence of syndecan-1 affects the gut microbiota and disrupts the homeostasis of microbes internally, increasing the likelihood of IBD development, and supported by data regarding polymorphisms in IBD susceptibility genes, this study explored and compared the IBD pathogenic process in syndecan-1 KO mice compared to wild-type Balb/c mice [22,23,24].