NFKB1 and Sepsis: The TA-Gen3 nanoparticle exerts its anti-sepsis activity by (1) binding cfDNA with high affinity and inhibiting cfDNA-induced activation of TLRs and NF-kB signaling; (2) inhibiting macrophage recruitment; (3) scavenging reactive oxygen species (ROS) and reducing ROS-induced DNA damage and cell death; (4) inhibiting nitric oxide production induced by bacterial lipopolysaccharides; and (5) providing potent antibacterial activity due to the presence of gentamicin.