MMT-SA microcapsules are considered to be an ideal drug-encapsulation and controlled-release vehicle for oral treatment of colon diseases due to their good biosafety for human gastrointestinal cells (HIEC-6 cells and NCM460 cells) as well as the improved microporous structure with enhanced swell–dissolution properties in SIF and SCF (alkaline environment). Here, KITLG is linked to colonic disorder.