In C6 glioma cells, there was an increase in S100B protein secretion compared to the basal group (Figure 1A, p = 0.0032), while in primary astrocyte cultures’ (Figure 1B, p = 0.0002) acute hippocampal slices, we observed a decrease in S100B secretion compared to the basal group (Figure 1C, p < 0.0001). This evidence concerns the gene S100B and central nervous system cancer.