According to the core target information, MAPK3, AKT1, HSP90AA1, ESR1, RELA, TP53, STAT3, IL2, NFKB1, LCK, JUN, MAPK14, EGFR, ADRBK1, PRKCD, PRKCA, and PRKCZ, which ranked high, might be key targets for the treatment of AD. Here, ESR1 is linked to Alzheimer disease.