ESR1 and Alzheimer disease: Among them, MAPK3, AKT1, HSP90AA1, ESR1, RELA, TP53, STAT3, IL2, NFKB1, LCK, JUN, MAPK14, EGFR, ADRBK1, PRKCD, PRKCA, and PRKCZ had higher degree values, indicating that they might be the key targets for the treatment of AD (Figure 1F).