CYP27B1 and melanoma: In regard to melanomas, there was an inverse correlation between CYP27B1 expression and Ki67 [26], and similar results were also obtained when analyzing ovarian tumors (the prevalence of positive Ki67 was markedly increased in the area without CYP27B1 expression compared with areas with positive staining of the enzyme) [47], as well as for thyroid cancers [49].