Considering the obtained results in the present study, which has proven a potential difference between cases with very mild psoriasis and moderate to severe psoriasis regarding the CYP27B1 enzyme in the epidermal layer, the limitations of this work are represented by the lack of numerous and homogenous study groups, including the lack of more healthy skin samples for a control group, which could reveal whether the results respect a certain statistically significance trend. This evidence concerns the gene CYP27B1 and psoriasis.