In an animal model, SAMP mice (which naturally develop segmental enteritis with cobblestone lesion formation in a fashion resembling Crohn’s disease) fed with Splenda (sucralose with maltodextrin) had increased myeloperoxidase (MPO) activity, but not in IBD-free mice, while dysbiosis (Proteobacteria enrichment) was observed in the control group [82]. The gene discussed is MPO; the disease is irritable bowel syndrome.