TIMP2 and hereditary clear cell renal cell carcinoma: Multiple pieces of evidence have linked elevated levels of TIMP-2 with the proliferation, invasion, and/or metastasis of BC [17,45,46], as well as other cancer types such as oral cancer [47], laryngeal cancer [48], colorectal cancer [49], renal cell carcinoma [50], bladder cancer [51], and prostate cancer [52].