Consequently, CagA-induced proinflammatory cytokines, interleukin (IL)-1, IL-6, IL-18, tumor necrosis factor α (TNFα), and interferon-γ (IFN-γ) [30,31,32], will increase, triggering gastric mucosa inflammation and atrophic gastritis. The gene discussed is IFNG; the disease is chronic atrophic gastritis.