CRP and congestive heart failure: In this regard, Pasini et al. showed that in 60 patients with mild CHF (NYHA functional class I to II) and moderate to severe CHF (NYHA functional class III to IV) that, compared with normal control subjects, the entire CHF population showed significant increases in intestinal permeability (assessed by cellobiose sugar test) and venous blood congestion (expressed as by echocardiography), together with systemic inflammation parameters (CRP).