Thus, with the aim of investigating the associations among the aqueous humor levels of the novel inflammatory factors Flt-3L, fractalkine, CXCL-16, and endocan-1; the severity of macular edema in CRVO; and the prognosis of CRVO with macular edema after anti-VEGF therapy, the present study measured the aqueous humor levels of VEGF and the novel inflammatory factors in CRVO patients and macular edema to investigate the associations of each inflammatory factor, the severity of macular edema in CRVO patients, and the prognosis of macular edema in CRVO after anti-VEGF therapy. Here, VEGFA is linked to macular retinal edema.