BIRC5 and cancer: As per the QPCR array data, Rapamycin is believed to induce apoptosis in cancer cells by altering the components of the extrinsic (CD40LG, DAPK1, LTA, TNFRSF21) and intrinsic (BIRC5, BNIP3) apoptotic pathways as well as the TP73 upstream modulator.