Our study of 58 cases of intrahepatic cholangiocarcinoma (ICC) revealed an elevated mRNA expression of all PDGF isoforms (PDGF-A, PDGF-B, PDGF-C, and PDGF-D), along with their corresponding receptors PDGFR-α and PDGFR-β in cancerous tissues compared to adjacent hepatocyte-rich tissue. The gene discussed is PDGFD; the disease is intrahepatic cholangiocarcinoma.