CASP3 and colonic neoplasm: Figure 14 shows that both colon cancer cell lines were characterized by a dose-dependent depolarization of Δψm after 24 h of treatment, either with berberine or its liposomal formulation. It was previously reported that caspase-3-negative cell lines were characterized by a similar fold change in the decrease of Δψm after 48 h of treatment [38]. Figure S15 shows that both colon cancer cell lines were characterized by a dose-dependent hyperpolarization of Δψm after 48 h of treatment, either with berberine or its liposomal formulation.