There was a significant correlation between the IC-SCC tumor grading and LAG-3 (p < 0.0163), TIM3 (p = 0.014), PD-L1 in the tumor (p < 0.0001), and PD1 (p = 0.029) in IC-SCCs, but none for EB-SCCs and IS-SCCs. This evidence concerns the gene PDCD1 and neoplasm.