This includes the transition from MITFhigh/NF-κBlow to MITFlow/NF-κBhigh/AXLhigh during the development of melanoma resistance [67,68], transition from primary melanoma that expresses ZEB2high/SNAIL2high/ZEB1low/TWIST1low to metastatic melanoma expressing ZEB2low/SNAIL2low/ZEB1high/TWIST1high [69], transition of melanoma of the ABCB5+ subpopulation to the melanoma ABCB5−subpopulation [70,71,72,73], and transition of the melanoma CD133+ subpopulation to the melanoma CD133− subpopulation [73,74,75,76,77]. The gene discussed is ABCB5; the disease is melanoma.