This pro-tumor effect of Utx knockout in vivo primarily occurs through upregulation of an enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), a histone-lysine N-methyltransferase, and, subsequently, histone H3 lysine 27 (H3K27) me3 levels, suggesting that UTx is a crucial epigenetic regulatory factor in lung tumor development. Here, EZH2 is linked to neoplasm.