KRAS and neoplasm: Using CRISPR/Cas9 and Cre-LoxP gene knockout in a mouse model of Kras-G12D lung adenocarcinoma, Zhong et al. [45] found that loss of SOX9 significantly reduced the incidence, burden, and progression of mutant KRAS lung tumors by promoting anti-tumor immunity, suggesting a role for SOX9 in regulating the tumor microenvironment.