KRAS and pancreatic ductal adenocarcinoma: Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are the most common genetic alterations in human tumors [1], predominantly found in pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and lung adenocarcinoma (LUAC) [2], affecting over 95%, 40%, and 30% of the patients, respectively [3].