DNA methyltransferases (DNMTs), histone deacetylases (HDACs), EZH2, bromodomain protein 4 (BRD4), and lysine-specific histone demethylase 1A (LSD1), which play important roles in tumor biology, have also been shown to regulate anti-tumor immunity as well [71,72]. The gene discussed is BRD4; the disease is neoplasm.