This analysis revealed that the vast majority of direct CIC-DUX4 target genes (83/93) displayed decreased expression upon the fusion protein depletion, including a set of well-established CDS-tumor specific markers (ETV1, ETV5, DUSP4, ETV4, SPRED3) [29] (Figure 2F andTable S5). The gene discussed is DUSP4; the disease is neoplasm.