This is in stark contrast to the genomic distribution of other sarcoma-driving fusion proteins (including EWS-FLI1 [8], EWS-ATF1 [4], and EWS-WT1 [28]), which preferentially bind to distal sites, but is reminiscent of the genomic distribution of wt CIC occupancy in normal cells [29,30]. Here, EWSR1 is linked to sarcoma.