Several studies, including from our own group, have examined the biology and mechanisms involved in various translocated sarcoma models and described the distinctive features of specific onco-fusion proteins, including EWS-FLI1, EWS-ATF1, and EWS-WT1, which drive Ewing sarcoma, clear-cell sarcoma, and desmoplastic small round-cell tumors, respectively [4,8,9,10,11,12]. The gene discussed is EWSR1; the disease is clear cell sarcoma.