Overall, the ongoing debate concerning the role of POX/PRODH in cancer has led to the tentative conclusion that for a tumor to thrive, POX/PRODH must be silenced, a position supported by studies such as that by Liu et al., where POX/PRODH was found to be downregulated in a large group of various cancers paired with unaffected parent tissue used as a reference [36]. Here, PRODH is linked to neoplasm.